Moreover, serum MPO levels and activities correlated significantly with changes in MLD, diameter stenosis and CCSS before and after adjustment for parameters including age, sex, body mass index (BMI), history of hypertension, smoking, estimated glomerular filtration rate (eGFR), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), Log CRP levels, antiplatelet and statin use (all P < 0.001) (Table 4). This evidence concerns the gene MPO and hypertensive disorder.