In respect of GBM invasion, for example, as a result of EGFR amplification, ERK is upregulated and stabilizes YTH N6-methyladenosine RNA binding protein 2 (YTHDF2), thus promoting tumor propagation possibly due to repression of target genes expression, including L-xylulose reductase (LXRA) and HIVEP zinc finger 2 (HIVEP2)[60]. This evidence concerns the gene YTHDF2 and neoplasm.