Since our findings establish a critical role for LH3 in collagen α1α1α2(IV) biosynthesis, we predicted that PLOD3 might lead to clinical manifestations similar to those observed in individuals with COL4A1 and COL4A2 pathogenic variants causing Gould syndrome, a multisystem disorder frequently manifesting as fetal and perinatal ICH (13, 14, 15, 67, 68, 69, 70). This evidence concerns the gene COL4A2 and COL4A1/A2-related disorder.