Consistent with this finding, Plod3 deficiency in the mouse caused basement membrane defects (44, 45), suggesting that PLOD3 pathogenic variants may also contribute to intracerebral hemorrhages (ICHs), which constitute a central pathophysiological hallmark of Gould syndrome caused by COL4A1 and COL4A2 pathogenic variants (13, 14, 15, 67, 68, 69, 70, 71). This evidence concerns the gene COL4A2 and COL4A1/A2-related disorder.