AKT1 and cancer: KEGG pathway analysis showed that P4HA2 was mainly enriched in focal adhesion, ECM receptor interaction, regulation of actin cytoskeleton, cellular metabolism-related pathways, including proteoglycans in cancer, glycolysis/gluconeogenesis, biosynthesis of amino acids, and several important intracellular signaling pathways, e.g., the PI3K-Akt, MAPK, and HIF-1 signaling pathways (Fig. 5C–D).