Studies have confirmed that P4HA2 participates in the metastasis of oral squamous carcinoma, breast cancer, and prostate cancer.10, 11, 12, 13 In brain tumors, P4HA2 promotes cell proliferation and migration in glioblastoma through the PI3K/AKT pathway.14 This evidence concerns the gene P4HA2 and Familial prostate cancer.