However, when the level of NADPH inside tumor cells is elevated, it can turn into a building block of plasma membrane in rapidly growing tumor cells, which would assist the repairment of the damaged DNA in tumor cells and inhibit their immunogenic death and PD‐L1 upregulation.[13] Therefore, selective depletion of NADPH in tumor cells is the key to solve the puzzle of RT‐based treatments of TNBC. This evidence concerns the gene CD274 and neoplasm.