In the present study, we extended our previous findings on the KLF11 role in ischemic stroke and found that genetic deletion of KLF11 promotes infiltration of peripheral neutrophils and macrophages to the brain parenchyma in mice after brain trauma, implying that KLF11 genetic deficiency may cause BBB structural damage and functional disorders, which needs to be further investigated. Here, KLF11 is linked to injury.