During brain trauma, WT mice exhibited significant demyelination and axonal damage when compared with sham controls, showing a reduced relative OD value of LFB staining (Fig. 4C), decreased MBP fluorescence intensity (Fig. 4E), increased SMI32 fluorescence intensity (Fig. 4F), and an increased SMI32/MBP ratio (Fig. 4G) in the peri-lesional CTX, EC, and STR regions. Here, MBP is linked to injury.