In this model, the IFITM3 rs6598045 GG genotype was correlated with an increased risk of COVID-19 mortality (P < 0.0001, OR 18.51, 95% CI 14.31–23.96). Also, after adjusting for gender and frequency of the IFITM3 rs6598045 polymorphism, COVID-19 mortality was associated with the IFITM3 rs6598045 GG (OR 19.02, 95% CI 13.24–27.32 in male vs. OR 19.06, 95% CI 13.09–27.75 in female) and AG (OR 7.69, 95% CI 5.71–10.36 in male vs. OR 7.24, 95% CI 5.34–9.81 in female). The gene discussed is IFITM3; the disease is COVID-19.