To explore the role of the CCL2/CCR2 and CXCL8/CXCR2 axes in HCC, expression of CCL2, CCR2, CXCL8, and CXCR2 was evaluated by immunohistochemistry in tissue microarrays of tumors from a retrospective cohort of 74 HCC specimens with complete follow-up data. This evidence concerns the gene CXCR2 and hepatocellular carcinoma.