The depth and breadth of data obtained in such multiple seizure models can shed light on the different aspects of the plant extract under consideration: MOA, potential targets for antiepileptic interventions, possible bioactive compounds, etc. In addition to PTZ and MES, one or more of the following stimuli such as INH, PIC, PLC, NMDA, STR, AMP, and BIC are used to induce convulsions (in experimental animals) in epilepsy research. This evidence concerns the gene HSPG2 and epilepsy.