The first candidate gene study on ARDS dates to 1992 (on angiotensin-converting enzyme [ACE] polymorphism) [56], the first candidate gene study validation was developed in 2000 and 2002 [57, 58], the first gene and genome-wide association study (GWAS) was developed in 2012 [53], and the first next-generation sequencing dates to 2014 [54]. The gene discussed is ACE; the disease is acute respiratory distress syndrome.