In B lymphocyte subsets, it is worth noting that the number of plasma blasts was markedly increased in COVID-19 patients, with IL-6 levels above 30-fold higher than normal (Fig. 5B), but other B lymphocyte subsets, including naïve B cells, transitional B cells, class switched memory B cells, class unswitched memory B cells, marginal zone B cells, and CD21low CD38low B cells, were obviously decreased with higher IL-6 levels (Fig. 5B). This evidence concerns the gene IL6 and COVID-19.