In the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, splenic MDSCs are composed of two subpopulations: polymorphonuclear-MDSCs (PMN-MDSCs, CD11b+Ly-6CintLy-6G+) and monocytic-MDSCs (M-MDSCs, CD11b+Ly-6ChiLy-6G−, which are phenotypically indistinguishable from Ly-6Chi inflammatory monocytes in blood, i.e., Ly-6Chi cells [20]). The gene discussed is ITGAM; the disease is experimental autoimmune encephalomyelitis.