LGALS9 and infection: Additionally, authors were able to show that the administration of Gal-9 to CVB3 infected mice showed reduced CD4 + T-cells, but increased Treg in the heart tissue 7 days post infection, which was complimented by decreased Th1 cell cytokines (TNF, IFN), but increased Th2 cytokines (IL-4, IL-10) [115].