The expression of Smad interacting protein 1 (SIP1, also known as ZEB2), a member of the ZEB group of transcription factors, plays a role in the impairment of colony formation and invasion of tumorigenic glioma cells through the regulation of E-cadherin and mesenchymal proteins, such as fibronectin and vimentin [157]. The gene discussed is ZEB2; the disease is central nervous system cancer.