Several studies have shown that ZEB1, along with other factors such as TWIST, Snail, and Slug, is an important transcription factor involved in EMT promotion in the CNS and plays an important role in the pathophysiology of different neurological disorders, including brain tumors, neuropathic pain, acute ischemic stroke, and MS (Fig. 3; Table 2). The gene discussed is ZEB1; the disease is brain neoplasm.