Alfa-6-integrin, a regulator of GBM proliferation and stemness, regulates the expression of GBM stem cells via the modulation of the ZEB1/YAP1 transcription complex that leads to enhancement of cell proliferation and stemness via the stimulation of the forkhead box M1 gene [144] and promotes radioresistance of GBM cells through the modulation of DNA damage response [145]. The gene discussed is YAP1; the disease is glioblastoma.