In atopic dermatitis, circ_0004287 reduced the stability of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) by competitively binding to insulin-like growth factor 2 mRNA-binding protein 3, with MALAT1, in an N6-methyladenosine (m6A)-dependent manner to inhibit M1 phenotype macrophage activation [10]. Here, MALAT1 is linked to atopic eczema.