It is worth noting that the four most significant targets, GABRA1 (GABAA receptor α1 subunit), GABRB2 (GABAA receptor β2 subunit), GABRA5 (GABAA receptor α5 subunit) and GABRG2 (GABAA receptor γ2 subunit) obtained from the final screening of cinnamon aqueous extract, were significantly enriched in the GABA signaling pathway, which may illustrate a dominant part of cinnamon aqueous extract in inhibiting AD-related GABAgeric synaptic dysfunction. Here, GABRB2 is linked to Alzheimer disease.