GABRA5 and major depressive disorder: For example, ( +)-Procyanidin B2 and Procyanidin B1 have high affinity with GABRA1, Methyl cinnamate and Myristicin have a potential high binding affinity with GABRA5 and GABRG2, etc. It has been reported in the literature that black hawthorn fruit, asparagus, and cocoa extracts, whose main component is procyanidins, reduce anxiety/depression symptoms in rats33–35.