Phosphorylation of Cc has also been related to several pathologies, such as ischemia/reperfusion injury, neurological disorders, and cancer progression32. Although phosphorylation mainly occurs on serine and threonine residues with high frequency, phosphorylation of tyrosine residues has a crucial role in the regulation of mechanisms directly relevant to mitochondrial and cancer signaling, such as metabolic homeostasis, differentiation, and proliferation33,34. The gene discussed is CXCR1; the disease is cancer.