In conclusion, COS attenuates oxidative stress-induced renal damages, probably by decreasing free radicals, maintaining the activities of anti-oxidative enzymes, and inhibiting the activation of NF-κB and in disagree with Ji et al.69 who reported that GA induced apoptosis in NCI-H460 lung cancer cells via a caspase-3 and inhibited the in vivo tumor growth of NCI-H460 cells in xenograft models. This evidence concerns the gene NFKB1 and neoplasm.