Indeed, Smad7 regulates expression of HDAC6 in prostate cancer in response to TGF-β53 and HDAC6 may play an indispensable role in balancing the maintenance and activation of primordial follicles through mechanistic target of rapamycin (mTOR) signaling in mice54,55. The gene discussed is HDAC6; the disease is Familial prostate cancer.