For lung cancer, we found three cancer driver genes (HLA-A, CASP8 and LEMD2) and two CGC genes (HLA-A and CASP8) among the unreported genes, and one cancer driver gene (HLA-B) and one CGC gene (FGFR1OP) among the previously reported genes (Fig. 4C). Here, CASP8 is linked to cancer.