ESR1 and cancer: For breast cancer, we found a suggested breast cancer predisposition gene (RAD50), five cancer driver genes (IGHMBP2, ATXN3, KANSL1, IL6ST and MSH3) and five CGC (PPFIBP1, IL6ST, SS18, TRIP11 and TFG) genes among the previously unreported genes, and four cancer driver genes (CASP8, AKAP9, ESR1 and MEF2B) and four CGC gene (CASP8, MUC1, AKAP9 and ESR1) among the previously reported genes (Fig. 4C).