TMPRSS2 and Familial prostate cancer: For prostate cancer, we found four cancer driver gene (IGHMBP2, STK19, TEAD3 and ARL16) and four CGC genes (TRRAP, CARS, HOXA9 and POU5F1) among the previously unreported genes, and two cancer driver genes (CCND1 and ZFP36L2) and three CGC genes (TMPRSS2, SUFU and CCND1) among the previously reported genes (Fig. 4C).