RIGI and viral infectious disease: To assess the status of circRIG-I in Rig-ifs/fs mice, we used qRT-PCR assay and found that the transcription of circRIG-I was increased in Rig-ifs/fs MEFs with virus infection as relative to WT MEFs (Fig. 4m), which is contrast to the reduced mRNA level of Rig-i (Fig. 4a).