The importance of PPARγ in human adipocyte biology and physiology is underscored by the finding that many cases of familial lipodystrophy, a syndrome characterized by repartitioning of adipose tissue causing severe insulin resistance, type 2 diabetes mellitus (T2DM) and dyslipidemia, are caused by heterozygous point mutations in this transcription factor2 (FPLD3; OMIM 604367). Here, PPARG is linked to metabolic syndrome.