Also, proteins including Leptin (LEP), Phospholipase A2; membrane-associated (PLA2G2A), Follistatin-related protein 3 (FSTL3), and EGF-containing fibulin-like extracellular matrix protein-1 (EFEMP1) were significantly higher in the MOD subtype as they all associate strongly with obesity but did not differentiate between T2D cases and controls when adjusted for BMI. Here, FSTL3 is linked to obesity due to melanocortin 4 receptor deficiency.