Consistent with the criteria of tuft cell-like tumors and our above findings, representative tuft cell genes (e.g., POU2F3, GFI1B, and TRPM5) [8], as well as KRT5, BCL2, KIT, and MYC were among the 92 genes that were upregulated both in tuft cell-like SCLC and tuft cell-like LCNEC (Fig. 4B-C). This evidence concerns the gene KRT5 and large cell neuroendocrine carcinoma.