Indeed, lysosomes in cancer cells are more vulnerable to LMP due to oncogenes downregulating lysosomal membrane protection proteins, which are highly glycosylated glycoproteins.264 Additionally, hydrolysis of sphingomyelin, where lysosomal membranes are rich in, sensitizes cancer cells to LMP.258,265 Cancer cells with enlargeable lysosome size and number are thus more vulnerable to LMP-mediated apoptosis. Here, PDLIM7 is linked to cancer.