Among which, the expressions of anti-tumor cytokines including IL-2, IL-15 IL-17A, IFN-γ and TNF-α were up-regulated, while tumor-promoting cytokines including IL-4 and IL-10 were down-regulated in HER2.28ζ/PD-L1.BB CAR-T cells (Fig. 6d). This evidence concerns the gene IL15 and neoplasm.