As compared to HER2.28ζ CAR-T cells, HER2.28ζ/PD-L1.BB CAR-T cells exhibited superior cytotoxicity against all the three HER2+/PD-L1+ tumor cells (SKOV3PD-L1, A549 and H1975), particularly when cultured with SKOV3PD-L1 cells that had the highest HER2 and PD-L1 expressions among all target tumor cells. Here, CD274 is linked to neoplasm.