Compared to persons with severe hemophilia and no measurable FVIII level, the ABR was reduced by 50% at a FVIII level of 3.1 IU/dL, by 75% at a FVIII level of 9.3 IU/dL, and by 90% at a FVIII level of 28.0 IU/dL. The gene discussed is F8; the disease is hemophilia.