F8 and hemophilia: In our study, the bleeding hazard for a constant FVIII level of 0.5 IU/dL was estimated to give 1.3 bleeds per year (95% CI: 0.5–2.1), which is lower than the 2.8 bleeds per year with a constant FVII level of 0.5 IU/dL estimated by Abrantes et al16in an RTTE analysis of the BAY 81-8973 clinical trial data in severe hemophilia.