BDNF and endocrine system disorder: BDNF is a growth factor and a member of the neurotrophic factor family.[65] After platelets activate BDNF, angiogenesis-related and inflammatory cytokines are released, while NR can regulate platelet activation, aggregation, secretion, and promote the expression of BDNF factor, exhibiting good antiplatelet activity and antidepressant effect.[66,67 ASD patients are associated with a higher prevalence of obesity, overweight, and cancer due to their endocrine disorders.