Current evidence suggests that NR can control cell apoptosis and maintain cell activity by regulating AKT1 target proteins.[47] At the same time, NR can significantly inhibit AKT1 phosphorylation, promote gene transcription and protein synthesis, and activate Akt-mTOR signaling to inhibit apoptosis in autism and alleviate abnormal social behavior in mice.[48,49]. The gene discussed is AKT1; the disease is autism.