The relationship between obesity and diseases of various systems is a hot issue worldwide, and most diseases have been confirmed linked to obesity.[1] IgAN is a common clinical primary renal disease characterized by the deposition of IgA in the mesangial region of the glomerulus.[2,3] About 10% to 20% of patients will progress to end-stage renal disease (ESRD) within 10 years, so it is necessary to explore the factors associated with the progression of IgAN to prolong the survival time of patients and improve the quality of life of patients. Here, CD79A is linked to obesity due to melanocortin 4 receptor deficiency.