Excluding hemolytic Hb (Hb S),[2] abnormal oxygen affinity Hb[3] and thalassemia-like abnormal Hb (such as Hb E),[4] which obvious functional changes have occurred, the phenotype of the carriers of most individuals with other abnormal Hb conditions is normal (https://globin.bx.psu.edu/hbvar/menu.html). Here, GSTM1 is linked to thalassemia.