CX3CR1 and metabolic dysfunction-associated steatohepatitis: Deletion of CX3C chemokine receptor 1 has a negative effect on intestinal barrier function and aggravates steatohepatitis in NASH mice.[16] Some findings suggest that the intestinal barrier dysfunction increases liver permeability and bacterial translocation, leading to NASH induction.[17] Therefore, the pathogenesis of NASH maybe caused by multiple factors, and more research is needed to solve the mystery.