Lin et al found that the protein expression of CKS2 was positively correlated with Akt phosphorylation.[12] Akt can further promote IKK phosphorylation and activate the NF-κB pathway, which promotes the release of CXCL16 and IL-8 by keratinocytes, and an increase in CXCL16 can lead to the migration of CD8 + T cells in patients with vitiligo.[13] We speculated that CKS2 might participate in the development of vitiligo through an immune response. The gene discussed is CKS2; the disease is vitiligo.