RAC1 and cancer: From the correlation plots of the top 16 chemotherapy drugs (Fig. 9), it is observed that an increase in PPIA, HDAC1, and ISG20L2 expression was associated with increased drug sensitivity to hydroxyurea, acrichine, nelarabine, and allopurinol, whereas the expression of CD320, RAC1, and BIRC5 may be related to cancer resistance to dasatinib, fluorouracil, and ARRY-162.