FGA and cyclic hematopoiesis: Mutation of the fibrinogen alpha chain gene (c.104G > A) was revealed using gene sequencing in our patient, which is 1 of the hotspot mutations.[7] However, minimal data describe how patients with this mutation are treated during the perioperative period, and major schemes are provided based on CH.[4] We suggest that the relationship between variants and phenotypes must be further researched; however, the absence of an accurate relationship makes it impossible to directly assess the risk of bleeding and thrombosis.