ACHE and Alzheimer disease: DH, as a second-generation cholinesterase inhibitor used for mild to moderate AD, could reversely inhibit acetylcholinesterase to facilitate cholinergic nerve transmission.[19] In previous AD meta-analysis studies, TKD + DH enhanced overall effective rate pass beyond DH alone (OR 2.74, 95% CI: 1.55–4.85, P = .0006).[16] When combined with other TCM decoction, the cognitive decrement of moderate and severe patients were significantly retarded, which was generally stable within 2 years in mild patients.[20]