Donepezil hydrochloride (DH) is one of the drugs approved by the Food and Drug Administration for the treatment of AD, which has pharmacological effects by affecting cellular and molecular processes of neurodegeneration.[5] DH can selectively inhibit acetylcholinesterase activity, interfere with the expression of AChE-S type, enhance the expression of R-subtype, and produce neuroprotective effect.[6] Although DH is the drug for the treatment of AD, there are still certain problems. This evidence concerns the gene ACHE and Alzheimer disease.