UHRF1 and cancer: PAAD cells have extensively reprogrammed metabolism, which is driven by oncogene-mediated cell-autonomous pathways, the unique physiology of the tumor microenvironment, and interactions with non-cancer cells.[24] Hu et al found that UHRF1 promotes aerobic glycolysis and proliferation in PAAD.[25] Tumor cells of PAAD utilized “metabolic reprogramming” to satisfy their energy demand and support malignant behaviors including metastasis.