SMAD2 and neoplasm: For example, linc00462 promotes PAAD proliferation, cell migration, invasion, and tumor metastasis through the Smad2/3 pathway.[15] What’s more, KIF23, NUSAP1, and SMC4 enhanced cell proliferation and invasion and acted as potential biomarkers for the diagnosis and prognosis of PAAD.[16–18] Our results showed that due to the high expression of CENPA in PAAD, CENPA was initially identified as an oncogene and confirmed that its expression was related to tumor invasiveness.