For example, linc00462 promotes PAAD proliferation, cell migration, invasion, and tumor metastasis through the Smad2/3 pathway.[15] What’s more, KIF23, NUSAP1, and SMC4 enhanced cell proliferation and invasion and acted as potential biomarkers for the diagnosis and prognosis of PAAD.[16–18] Our results showed that due to the high expression of CENPA in PAAD, CENPA was initially identified as an oncogene and confirmed that its expression was related to tumor invasiveness. This evidence concerns the gene SMC4 and pancreatic adenocarcinoma.