Through KEGG pathway enrichment analysis, it was found that Liuwei Dihuang Pill played an important role in the treatment of tinnitus, including HIF-1 signaling pathway, Influenza A, P53 signaling pathway, and Toll-like receptor signaling pathway, which might play a role in anti-inflammatory, improving microcirculation in the blood-labyrinth barrier, increasing cochlear blood flow, and preventing hair cell damage. Here, TP53 is linked to Tinnitus.