In previous studies, astragalus polysaccharides were shown to suppress the proliferation and invasion of tumor cells by upregulating miR-195-5p in nonsmall cell lung cancer[26] miR-195 has also been reported to inhibit the proliferation and enhance apoptosis of OSCC cells by targeting TLR4,[27] while miR-195-5p was shown to inhibit the viability and proliferation and promote apoptosis of HUVECs.[28–30] However, to the best of our knowledge, the effects of miR-195-3p on hypoxia-induced HUVECs have rarely been reported. The gene discussed is TLR4; the disease is lung cancer.