In addition, changing therapeutic schedules is also an option; for example, for patients with advanced-stage EGFR-mutant lung cancer who need to use PPIs, afatinib or osimertinib may be a better choice than gefitinib.[28] Interestingly, some studies found that with TKI administration combined with acidic beverages (such as cola and soda), betaine HCl may lead to temporary gastric re-acidification, which may facilitate the dissolution, solubilization, and absorption of the TKI within the critical absorption window.[16,17,28,42]. Here, EGFR is linked to lung cancer.