CRP and rheumatoid arthritis: Compared to younger-onset rheumatoid arthritis (YORA), which presents before the age of 60 years, LORA has unique characteristics and disease manifestations such as a higher proportion of males, more comorbidities, less frequent positivity for rheumatoid factor or anti-cyclic citrullinated peptide (anti-CCP) antibody, higher C-reactive protein (CRP), and higher erythrocyte sedimentation rate (ESR) [5].