Notably, rCD248D1-4 treatment did not alter tumor CD248 expression (Fig. 6D); however, it reduced the expression of PAS+/CD31− vessel-like structures (as demonstrated in the insert of Fig. 6E) (Fig. 6E, F) and the expression of MMP9 in the tumor nodules (Fig. 6G, H). This evidence concerns the gene MMP9 and neoplasm.