Tumor immune profile seems to have a greater influence on the prognosis of BRCA-mutated and BRCA WT HRD-high tumors (compared to BRCA WT HRD-low cases), since high expression of B cell lineage, dendritic cells, cytotoxic T lymphocytes, T cells, and CD8 T cell signatures appear to be more strongly associated with favorable survival in these groups of tumors (Fig. 5C-D). The gene discussed is CD8A; the disease is neoplasm.