Haney et al. performed multiple MACS- or FACS-based genome-wide CRISPR knockout screens in a human myeloid cell line (U937) to find genes modulating the phagocytosis of a variety of phagocytic substrates, uncovering a role for TM2 domain-containing protein 3 (encoded by the AD risk gene TM2D3) in modulating uptake of amyloid beta aggregates [56]. The gene discussed is TM2D3; the disease is Alzheimer disease.