DCs have crucial roles in bone metabolism [187], including: 1) contribution to inflammation-mediated osteoclastogenesis and participation in inflammatory bone disease; 2) activation of T cells that produce bone remodeling cytokines and soluble factors; 3) pathogenesis of postmenopausal osteoporosis; 4) and transdifferentiation into osteoclasts in the presence of RANKL and macrophage colony-stimulating factor (M-CSF) or IL-17, wherein RANKL/RANK regulates the immune crosstalk between CD4 T cells and DCs. Here, TNFSF11 is linked to postmenopausal osteoporosis.