Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed the differential gene enrichment was related to a variety of signaling pathways including proteins processing in endoplasmic reticulum (ER) stress and hypoxia induction, suggesting that HNRNPA2B1 plays an important role in ER stress in the regulation of myeloma (Fig. 3D). This evidence concerns the gene HNRNPA2B1 and plasma cell myeloma.