With regard to TLR4 expression in MM patients, we found that the TLR4high subgroup had significantly poorer survival, including both OS and PFS, compared to the TLR4low subgroup in two independent datasets of GSE136400 (Fig. 6D and E, P = 0.0095, 0.0114, respectively) and GSE4204 (Fig. 6F, P = 0.0397). Here, TLR4 is linked to Miyoshi myopathy.