The immune checkpoint TNFSF14 in Neutrophils, NK Cells, and Monocytes and BTLA in Treg Cells, Granulosa Cells, and B Cells interact with LTBR and TNFRSF14 in Cancer Cells to mediate cytotoxicity and promote tumor killing [31–34]. The gene discussed is TNFRSF14; the disease is neoplasm.