After overexpression, it was found that the activities of signal pathways such as IL-17 signaling pathway were significantly up-regulated (Fig. 6K), and CD177 was positively correlated with the abundance of most immune cells (Additional file 4: Fig. S4E), suggesting that CD177 plays an immune effect of chemotactic neutrophils in NSCLC. The gene discussed is CD177; the disease is non-small cell lung carcinoma.