It indicated that RETN helped improve the chemotaxis of immune cells, and tumors could ensure their survival by down-regulating RETN. It has been reported that the CSRNP1 gene can be used as a prognostic biomarker [45, 46] for many cancers, indicating the essential prognostic value of CSRNP1. When CSRNP1 is simulated to be down-regulated, the activities of various biological modification-related pathways, including Spliceosome activity, are down-regulated. The gene discussed is RETN; the disease is cancer.