CXCR2 and neoplasm: After the low expression of CXCR2, it was found that the immune activity-related pathways such as Cytokine and Cellular Calcium Ion Homeostasis also showed a down-regulated state (Fig. 6I), indicating that tumor down-regulated some immune stress responses by decreasing the expression of CXCR2 to ensure that it was not killed by immune cells.