Chemokines CXCL1, CXCL2, and CXCL8 are highly expressed in Cancer Cells and act on CXCR1 and CXCR2, which are highly expressed in Neutrophil chemotactic the activity of Neutrophils and promote the generation of tumor immune microenvironment. This evidence concerns the gene CXCR2 and neoplasm.