Univariate analysis of survival revealed that pTNM stage (P = 0.018), peritoneal metastasis (P = 0.014), lymphatic metastasis (P = 0.004) and vascular invasion (P = 0.008), high expression of FAP (P = 0.018) and EZH2 (P = 0.034) were prognostic indicators of OS (Table 2); vascular invasion (P = 0.009), lymphatic metastasis (P = 0.008) and high expression of FAP protein (P = 0.006) were prognostic indicators for DFS (Table 3). This evidence concerns the gene FAP and metastasis.