EZH2 in CAFs can participates the peritoneal tumor formation of GC by demethylating H3K27me3 markers [28]; On the other hand, CAFs-derived VEGF promoting the proliferation and angiogenesis of human umbilical vein endothelial cells via regulating EZH2/VASH1 pathway [26]. Here, EZH2 is linked to neoplasm.