Multivariate Cox regression analysis showed that high expression of EZH2 (P = 0.033) in addition to lymphatic metastasis (P = 0.014) were independent risk factors of OS (Table 2); whereas high FAP protein expression (P = 0.018) in addition to lymphatic metastasis (P = 0.017) were independent prognostic indicators for DFS in GC patients (Table 3). This evidence concerns the gene EZH2 and gastric cancer.