The correlation of WL% with this simple classification was consistent after adjusting for age, sex, the season which the last visit was done, menopausal status, baseline BMI, follow-up duration, anti-thyroid antibody positivity, the presence of diabetes or prediabetes, serum calcium levels, cumulative doses of levothyroxine, metformin, orlistat, acarbose, sodium-glucose cotransporter-2 inhibitors, exenatide, basal insulin, insulin secretagogues, diuretics, beta-blockers, and fluoxetine medications (r = 0.31, p < 0.001). The gene discussed is INS; the disease is prediabetes syndrome.