These observations are in agreement with Roberts et al. [10], who reported a direct correlation between obesity and testosterone levels in women, and Coradini et al. [15] who observed that adipose tissue is involved in regulating the production and bioavailability of sex hormones, for instance in converting testosterone to estradiol via aromatase. The gene discussed is CYP19A1; the disease is obesity due to melanocortin 4 receptor deficiency.