Previous studies have demonstrated that SIGIRR influences chronic inflammatory or autoimmune diseases, such as intestinal inflammation, systemic lupus erythematosus, and psoriatic inflammation, by regulating the activities of NK cells, CD8 T cells or γδ T cells (Wang et al. 2022; Wang et al. 2013; Molgora et al. 2017; Xiao et al. 2007; Russell et al. 2013). The gene discussed is CD8A; the disease is gastroenteritis.