SIGIRR and autoimmune disease: Deregulated activation by TIR ligands in IL-1R8-deficient mice has been associated with exacerbated inflammation and immunopathology, including autoimmune diseases or selected cancers (Molgora et al. 2017; Riva et al. 2019; Xiao et al. 2007; Aiello et al. 2020; Wald et al. 2003; Giannoudaki et al. 2021).